IVD solution for rapid antibiotic susceptibility testing (AST)

QuickMIC™ for susceptibility guidance within 2 hours

Based on our patent-pending and proprietary microfluidic technology solution to create stable substance gradients, Gradientech is developing an in vitro diagnostic solution for rapid antibiotic susceptibility testing of positive blood culture samples. By real-time monitoring of bacterial growth and quantification of micro-colonies within precise antibiotic gradients, phenotypic susceptibility guidance is maintained within only 2 hours. This is at least 20 hours faster compared to traditional culture-based methods used for AST in clinics today.

 

Same day results for all sepsis patients

RapidAST_Workflow

QuickMIC™ generates phenotypic AST results in only 2 hours, which is at least 20 hours faster compared with clinics today. 

The introduction of MALDI mass spectrometry within clinical diagnostics has in short time become the golden standard for rapid and cost-effective bacterial identification. Our QuickMIC™ solution for rapid AST can be applied in parallel with, or following bacterial identification. This optimized laboratory workflow enables any clinical laboratory to give susceptibility based antibiotic guidance within the same day as positive blood cultur is detected – for all sepsis patients.

 

Benefits of the QuickMIC™ solution

RAPID AST RESULTS

› Generates MIC-values and SIR interpretation in only 2 hours for Gram-negative bacteria

GIF_MICvsTIME_2

PHENOTYPIC FUNCTIONAL RESISTANCE

› Susceptibility results are based on viable bacterial growth monitoring and guide to effective antibiotic treatment, which is not possible with gene based resistance testing

DETECTS ANY RESISTANCE

› Universal solution that detects any functional resistance, not based on specific probes or image database comparison

 

Prevents and controls antibiotic resistance

A rapid diagnostic AST solution is highly impactful to sepsis patient outcome and hospital costs. Adequate antibiotics administration is also essential to combat the constantly increasing antibiotic resistance, as highlighted by e.g. WHO policies and the recent publication by Review on AMR.

 

Most recent publications

A Novel Microfluidic Assay for Rapid Phenotypic Antibiotic Susceptibility Testing of Bacteria Detected in Clinical Blood Cultures
December 14, 2016, PLoS ONE

Improved detection algorithms for label-free time-lapse cytometry of bacterial microcolonies for rapid AST
April 11, 2016. ECCMID 2016, Amsterdam, The Netherlands – EPOSTER